Conference Schedule

Day1: June 21, 2018

Keynote Forum

Biography

Audrey Gueniche has obtained her Pharmacist degree and PhD degree in Skin Biology more than 20 years ago. She is an expert in Immunology and Microbiology. Her main expertise is on Skin Topical Treatment and food supplement for skin and hair health, especially using probiotics, natural extract and bacterial extracts. She is currently a Senior Clinical Expert in Loreal Research and Innovation. She has a complete experience from the in vitro evaluations/ preclinical studies to clinical trials. Her passion is to always reinvent evaluation and find best fields of area in term of actives to promote. She have published over 100 papers in peer-reviewed journals, 5 chapters in books, 2 specials issues in journal where she was the invited Editor. She presented in over 70 international congresses and additionally she was personally invited to give more than 35 plenary conferences

Abstract

It is known that both oral probiotic’s ingestion (Beyond to their potential benefit in the intestinal microbiota) and topical application of bacterial extract i) may improve skin barrier function ii) may help to balance beneficial vs. harmful microflora iii) may upregulate skin immune response to opportunistic pathogens iv) may downregulate skin inflammatory reactions v) may modulate host gene expression to promote function and delivery of functional proteins to prevent skin diseases. Specifically, Vitreoscilla filiformis extract (a hydrothermal species) topically applied were shown to be beneficial on atopic dermatitis (AD), by stimulating antimicrobial peptide and immunomodulatory pathways (e.g., IL10, TReg) leading to reduce skin infection and inflammation. In addition, we demonstrated that alive Lactobacillus paracasei ST11 by oral route stimulate skin antimicrobial peptide, help skin barrier recovery and reduce skin inflammation leading to improve dandruff condition with a rebalance scalp microbiota. Thus skin microbiota is fundamental, a part of the skin innate immunity. Rebalancing the microbiota in case of skin disorders by probiotics either oral route or bacterial extracts by topical application have a good relevance.
 

Biography

Tracy Evans has graduated with honours, Phi Beta Kappa from Vassar College in New York. She attended Medical School at the University of Connecticut where she completed both her Medical School training and earned a Master’s degree in Public Health. She conducted research for the National Institute of Health for two years on Skin Cancer. She has completed her Residency in Dermatology at Emory University in Atlanta, Georgia. She was Fellowship trained and certified by the American College of Mohs Micrographic Surgery and Accreditation Council of Graduate Medical Education at the University of Pittsburgh Medical Center. She founded her private practice in San Francisco, CA in 2008.She has authored several articles and book chapters on skin cancer and Mohs surgery. She has presented at multiple national and international meetings for her research on cost, quality of life, and skin cancer outcomes.

Abstract

Melasma is a chronic skin disorder which is cosmetically complicated to treat due to rebound    phenomenon and irritant contact dermatitis from the treatments themselves. Multiple factors contribute to the pathology including ultraviolet radiation, hormonal alterations within the estrogen or progesterone pathways, genetic predisposition, inflammation, and increased prevalence in patients with Fitzpatrick skin types III-VI. We have achieved significant reduction of hyperpigmentation in women of all Fitzpatrick skin types without side effects, including exacerbation of existing pigmentation with a low energy, low density, non-ablative fractional 1927nm diode laser. Each patient was treated at a depth of 170 µm, 5 mJ, 2.5% coverage, 4 total passes, with 2-6 treatments at least 4 weeks apart. All patients were pretreated for at least four weeks with Skin Medica Lytera® 2.0 (am/pm), broad spectrum sunscreen SPF 46 with niacinamide(am), compounded hydroquinone 6% (HQ) with tretinoin 0.05%, hydrocortisone 0.5%, kojic acid 4% (pm). Immediately post treatment: Lytera® 2.0, compounded HQ , clocortolone pivalate 0.1% and broad spectrum SPF 46 with niacinamide. While melasma has a propensity for rebound, our patients remain clear of recurrence 6 months post therapy.
 

Biography

Tal Offer has completed her PhD from the Hebrew University of Jerusalem and Post-doctoral studies from University of California, Berkeley. She is the global manager of the Carotenoids Category in Lycored. She has been focusing on biochemical processes in nutrition and health for over 20 years and published papers on the mechanisms of antioxidants in reputed journals
 

Abstract

Skin exposure to ultra-violet (UV) radiation leads to a large range of damaging effects. The outcome includes erythema, premature skin aging and skin cancer. Photoprotection is commonly encouraged by either physical or chemical blockers. Yet, a dietary approach based on intracellular control of oxidative-stress would be ideal for better skin care. Nutrients which are important as complementary agents for sun-screen include carotenoids. Lycomato is a whole-food extract providing all the health benefits of the tomato with its synergistic activity of naturally occurring carotenoids including lycopene. Lycomato has consistently been shown in clinical-trials to protect the skin from erythema. Lycored has completed several studies evaluating the efficacy of Lycomato in healthy volunteers. Lycomato and Lutein treatment were recently reported to reduce molecular markers associated with photodamage. These protective effects can be associated with protecting the collagen and reducing wrinkles. The addition of carotenoids as ingestible protection can enhance the activity of UV filters by neutralizing the damaging oxidants. We measured the levels of UV-induced oxidants in layers of the epidermal tissues, treated with formulations containing UVB & UVA filters and phytonutrients following irradiation with 1.5 MED.  The results showed that the combination of topical sunscreen with carotenoids increase antioxidants levels in human skin and reduce oxidative stress in the tissue. The application of topical formulations containing carotenoids together with oral supplementation increases their levels in the skin by to almost 100%. Thus, the combination of topical sunscreen with systemic treatments of carotenoids (topical and ingestible) would be an effective approach to increase antioxidants levels in human skin and achieve protection. Lycomato and other carotenoids may compliment the traditional sun care and skin care products enhancing their performance by neutralizing the free radicals and also by imparting beauty benefits, such as increased skin density, thickness, smoothness, radiance and glow.
 

Biography

Anita Mandal has recieved her Medical degree from Wayne State School of Medicine. She went on to complete a Residency Otolaryngology-Head and Neck Surgery at Detroit Medical Center followed by a Fellowship in Facial Plastic and Reconstructive Surgery with the Glasgold Group for Plastic Surgery. In private practice since 1998, she is specialized in Facial Rejuvenation. She is certified by the American Board of Facial Plastic and Reconstructive Surgery.
 

Abstract

Facial volumization is an integral part of facial rejuvenation today. Facial volumization errors are increasingly common but can be reduced using a systematic approach for the treatment of key facial aesthetic subunits (FAU) which develop as shadows and contours unique to the aging face.  Objectives include: (1) description of FAU's unique to the aging face, (2) identifying key volume-deficient FAU's requiring treatment, (3) recognizing the lateral malar subunit's pivotal role in setting the framework for mid-facial volumization, (4) avoidance of the "submalar abyss", (5) when to fill vs. lift in the aging face, (6) Tips and pearls for minimizing volumization errors.
 

Tracks

  • Medical Dermatology | Cosmetics and Skin care | Affects and side effects of cosmetics | Aesthetic Surgical Procedures | Aesthetic Non-Surgical Procedures | Prevention & Treatment for skin diseases | Melanoma | Global Market of Cosmetology & Dermatology
Location: Atlantis 1
Speaker

Audrey Gueniche

Loreal Research and Innovation, France

Chair

Speaker

Tracy B Evans

California Pacific Medical Center, USA

Co Chair

Biography

Camila Folle is currently pursuing PhD at the University of Barcelona, Graduated in Pharmaceutical Science by London Metropolitan University in 2011, has completed a Masters in Cosmetics and Dermopharmacy in 2012 by CESIF Barcelona, including a year internship at ISDIN SA, and a Masters in Nanoscience and Nanotechnology (2015) by the University of Barcelona. At present, she is continuously Researching dermatological active ingredients applied nanotechnology and final formulations for her PhD thesis.
 

Abstract

Nanotechnology has recently increased their innovation researches in cosmetology and dermatology based on the enhanced capacity of penetrating active ingredients in the deeper layers of the skin. Several advantages are considered, such as, small particle diameter, sustained release and lower doses required for its efficacy since higher amounts can be retained inside the skin. This research relies on characterization of different types of nanosystems developed containing active ingredients encapsulated, thus, on the different types of suitable semi-solid final formulations for them. It involves their physical chemistry parameters, rheology, stability and biopharmaceutical behaviour. The aim of this research is to compare the nanosystems alone and their final formulations on their in vitro release profiles and their influence on ex vivo skin permeability parameters and enhanced capacity of retaining higher amounts of the actives inside the skin
 

Biography

Anil Rajput has completed his MCh (Master of chirurgiae) in plastic surgery from Gujarat, India. He is presently working as Chief in Plastic Surgery department in Teerthanker Mahaveer University, India which is top ranked private university in India. He has honoured by many awards in country in related field and operated more than 15000 major cosmetic and plastic surgeries in India and surrounding countries.
 

Abstract

Aim: Incidence of facial nevus in India is one in 1000 birth and in United Kingdom is increase day by day because of mixed population. This is very important for cosmetologist to treat such type of cases in non-operative methods or laser therapy.
Methods: Instruments or lasers which are using in these studies are as 1.) Nd: YAG (Q-Switched) Surgical laser 1064nm and combined with KTP 532nm, 2.) Er: YAG laser 2940 nm for nevus 3.) Pulsed dye laser 595nm for hypertrophy 4.) Light sheer diode laser 800 nm for hair removal and in cases those were not recovered by laser or recurrence cases were treated by conventional methods of reconstructive surgery. Rarely needs IPL and long pulsed Nd: YAG. Result: More than 90% cases are achieved good aesthetic and cosmetic recovery by laser and 10% cases had recurrence which was recovered by reconstructive surgical procedures and hypertrophy which was recovered by steroid injection and PDL laser.
Conclusion: According to my previous experience of more than 12 years in regarding field, for any type of nevus, is recovered by laser therapy only. But some cases had recurrence of lesion and hypertrophy which were recovered by any other methods
 

Biography

Dr. Amani Saad ,MD from Lebanon  was graduated from  Isfahan University of  Medical Sciences. She is a member of American Academy for Aesthetic Medicine. She is a student at Qweenmary's University of London (Aesthetic Medicine MSc- 2nd year). She has her own clinic in Beirut, Lebanon in which she worked and still in aesthetic medicine for fourteen years. She is the owner of Lebanese Aesthetic Medical Center in Beirut. She has been honoured for her presentation entitled News in the Treatment of Periorbital Hyperpigmentation in the Eurodermatology Conference in RhoFiera, Italy and also in Eurodermatology Conference in Paris, France. She has been a Speaker in IMCAS worldwide conference in Paris in Feb 2018. She has been honoured to be the judge of the postal presentations in the conference.  Her presentations will be published in the International Journal of Clinical and Experimental Dermatology and also, other presentations are on their way for publication

Abstract

Periorbital hyperpigmentation (POH), also known as eye bags or undereyes' hyperpigmentation, is a common worldwide complaint. POH has many causative factors hence the treatment differs widely. Many treatment modalities are available and are commonly used including different kinds of peelings, lasers, hyaluronic acid fillers or surgery. Regardless of the underlying cause of POH and hence the modality of treatment chosen, topical medications and cosmeceuticals are the most common treatments used nowadays. Many topical treatments are available and because they are minimally invasive, they are considered to be the first line treatment of POH. They are widely used alone or in combination therapy with any other procedure like laser or peeling as preoperative and postoperative topical therapy. Hydroquinone, retinoids, vitamins, minerals and peptides including new generation peptides are widely used in the treatment of POH with promising results. Our goal in this research is to assess current topical treatments available based on their effectiveness and safety profiles. Many topical treatments  are available and because they are the least invasive and cost ineffective they are considered to be the first line treatment of periorbital hyperpigmentation. Concealers and optical diffusers are widely used to minimize the dark hue due to many different  causes and are effective somewhat as a conservative treatment or as a concurrent treatment used with other treatment options. A wide range of effective therapeutic medicinal agents and cosmeceuticals are also widely used to treat periorbital hyperpigmentation in addition to sunscreens and sunblocks. Hydroquinone and other melanogenisis inhibitors with some effective protocols are discussed in detail. Other families of skin lightening agents are effective and are used in the periorbital area safely. Efficacy of Retinoic acid topical treatment is assessed and compared with laser resurfacing treatment(study)

Biography

Qian Xu is a member of the Royal College of Surgeons and the Royal College of Emergency Medicine, and she has been specialising in Facial Aesthetics since 2012. She is the founder of Skin Aesthetics clinics, which has 4 locations around London and Southampton. She was one of the lead aesthetics trainers at Harley Academy, and has recently left to set up her own Aesthetics 360 Business Academy, which aims to teach and support aesthetic practitioners in all aspects of their business to help them find success in a competitive market. She is passionate about raising the standards within medical aesthetics by not only teaching practitioners how to practice more safely, but also to go into it with the right attitude.
 

Abstract

We were all healthcare professionals before we went into medical aesthetics, and we are used to advice patients the treatment plan for making them feel better. In aesthetics, however, it’s a whole new ball game! In aesthetics, there is generally a culture of patients coming in telling you exactly what they want, and expecting you to deliver that result for them. While the doctor in you may think their lips are big enough, the business person in you is thinking about all the bills you need to pay. Do you treat or not treat? Who wins? With the rise of social media, the selfie culture and celebrities speaking openly about the procedures they have had done, this will be a dilemma that we will be having more and more. Many young girls feel insecure about how they look because they are constantly comparing themselves to strangers on Instagram. The prevalence of body dysmorphic disorder has been reported to be about 2% in the general population, but can be as high as 50% in a cosmetic surgery setting. However, these statistics are probably the last thing on your mind when you are struggling to make ends meet in your business. How can you build a profitable aesthetics business if you have to turn people away all the time? Well, you probably can’t. So the key is to attract the right kind of patients in the first place, and have a strict patient selection process. Putting patients’ best interests first is the only way to bring peace to the Doctor and the Entrepreneur, which will enable you to build an aesthetics business that will last the test of time.
 

Biography

E Neza has completed her PhD in Pharmaceutical Sciences from University of Siena, Italy. She was appointed as Lecturer of Pharmacognosy at Department of Pharmacy Aldent University. During the years 2005-2008, she worked as Analyst for microbiological quality of pharmaceutical products at pharmaceutical industry. Her research concerns safety of cosmetic products. She has published and lectured on subjects of cosmetic science and medicinal plants in different national and international journals.
 

Abstract

Microbiologically contaminated cosmetic products can cause serious damage to consumers and also affect the stability of these products. According to RAPEX database primary microorganisms of concerns found in cosmetic products were; Pseudomonas aeruginosa, Staphyloccocus aureus, Candida albicans, Burkholderia cepacia. Enterococcus species (E.faecium, E.gergoviae, E.cloacae), gram negative bacteria (Bacillus firmus, Rhizobium radiobater, Serratia maecescens, Achromabacter xylosoxidans, Klebsiella oxytoca, Klebsiella pneumonie, Pantoea agglomerans, Citrobater freundii), gram positive bacteria (Bacillus firmus) and mold species. Among the contaminated products eye-area cosmetics mouthwashes, lotions, toothpastes, tattoo inks were found. Cosmetic products with higher preservative concentration were recalled: methylisothiazolinone, triclosan, benzalkonium chloride. 46% of contaminated products contained botanical extracts, known as microbial nutrient in cosmetics. 76% among them were produced in countries belonging to European Union. 22% of products were produced in Germany. European consumers are exposed by microbiologically contaminated and over preserved cosmetic products. Contamination is more commonly associated with products claimed as natural or composed of natural ingredients. Microbial testing of botanicals is a key aspect of cosmetic products safety. It is urgent, that national authorities monitor natural compounds and microbial contaminations in cosmetic products.
 

Day2: June 22, 2018

Keynote Forum

Biography

Alicia Roso works for SEPPIC since 1986. She is a Chemical Engineer and has worked for 20 years in the cosmetic R&D team, firstly as Lab Technician then as Lab Manager. She joined the marketing team in 2006 as Product Manager and gained a marketing MBA from ESSEC business school in 2012. She was named as Air Liquide International Expert for health care formulation and emulsions in 2010. She is currently working as Scientific Communication Manager in the innovation direction team. She is Co-author of 23 patents on new ingredients or formulation technologies dedicated to cosmetology and dermopharmacy applications.
 

Abstract

In vitro reconstructed human tissue models are recognized as being sensitive and reliable models to replace or reduce laboratory animal use in preclinical studies. Dermo-pharmaceutical products target different body areas such as mucous membranes, healthy or damaged skin. The purpose of this work is to develop new and predictive in vitro experimental protocols in order to screen epithelia tolerance of ingredients, within the product development stage. Several 3D reconstructed models have been investigated. Among them, gingival and vaginal mucosa and injured skin were selected as relevant tools to widen our ingredient physiological applications (initially developed only for healthy skin). For mucosa, ingredients were applied at usual doses onto standard in vitro models, at progressive times. Cellular viability measurement (MTT test) led to irritation potential conclusion according to supplier recommendations. For damaged skin, an innovative 3D reconstructed human epidermis models (RhE) with a physically impaired barrier function was developed (reproducible mechanical superficial abrasion at stratum corneum level). The skin tolerance was determined by (1) cellular viability (MTT test); (2) barrier function (TEER measurement and Biotin permeability); and (3) morphological evaluation (Hematoxylin Eosin Staining). Ingredients with different chemical structures and functionalities were tested and compared to negative control. Model predictivity was challenged with short chain surfactants including Sodium dodecyl sulfate (positive controls) as well as benchmarks. This approach allows selection of suitable ingredients for each body area. Moreover, it helps to determine the well-tolerated doses of emulsifiers and thickeners, pillars of topical pharmaceutical formulations. The multiple endpoints analysis (MEA) designed for injured epidermis model enriches basic irritation information with cellular, morphological and functional effects, thus enabling to appreciate not only the toxicity but also the homeostasis recovery mechanisms. MEA opens perspectives of new experimental models.
 

Tracks

  • Cosmetology | Derma-Pathology | Hair Transplantation | Psoriasis | Advances in Cosmetology & Dermatology | Aging, Anti-Aging Science | Cosmetic Dermatology
Location: Atlantis 1
Speaker

Alicia Roso

SEPPIC, France

Chair

Speaker

Shu Maoguo

Xi’an Jiaotong University, China

Co Chair

Biography

Shu Maoguo, professor and Phd advisor, an outstanding plastic surgeon who specializes in the reconstruction of maxillofacial trauma, congenital malformation，microsurgery and cosmetic surgery, dedicates himself to operations involving cleft lip and palate. He is a volunteer of Operation Smile for many times as a surgeon. He received his PhD, MD, all in medicine, from the Forth Military Medical University. Now he is the director of the plastic and reconstructive department of the first affiliated hospital of Xi’ An Jiaotong University. Shu’s research interests include wound healing and distraction osteogenesis. Shu has two approved patents.  His theory and suture technique about wound closure were widely recognized by surgeons in plastic surgery and other departments in China. His published in journals such as Biomed Res and Biomaterials applications as the firth author or the correspondence author. He is a member of Chinese Medical Association (CMA) and Chinese Medical Doctor Association (CMDA) and leader in many sub-groups.

Abstract

Background: A successful wound suture should provide a firm tension-relieving closure, good wound-edge eversion, minimal intradermal extraneous materials and unobvious postoperative scar. However, this is not always achieved with a traditional standard technique.
Methods: Combined with mechanisms of wound healing, principles of plastic surgery and progresses of wound closure, the authors describe a modification of a wound closure method that can rapidly and reliably achieve these results. In this method, a wedge-shaped excision was adopted to obtain a trapezoid pattern transect, after which a modified fully buried vertical mattress suture technique was used to close the wound. The surgical sutures and needles were optimized in these techniques. These techniques were compared with the standard excision and suture techniques used for the same patient at different times after surgery.
Results: These modified techniques were used in thousands of wound closures in clinic. The wedge-shaped excision can facilitate good wound-edge eversion, and the modified fully buried vertical mattress suture can provide firm tension relief, optimal apposition and minimal intradermal extraneous materials. Compared with conventional excision and suture techniques, the described techniques brought about a better outcome in terms of hypertrophic scar prevention.
Conclusion: The described modified technique seems to be more efficient than conventional procedures used to prevent hypertrophic scar formation and it’s worth popularization.
 

Biography

Endang Purwati has completed his PhD from University Putra Malaysia in Biotechnology Molecular Probiotic/ Food Safety/ Molecular Microbiology and Post-doctoral studies from Bogor Agricultural Institute of Sains Veteriner/ Parasitologi. She has been Professor in University of Andalas from 2005. She is the Head of Program Study of Post-graduation in Biotechnology, University of Andalas, and she is Chairman of the Regional Commission of Genetic Resources Organization, and Head of Laboratory Biotechnology/ Technology of Product Husbandry Faculty of Animal Science, University of Andalas. She has published more than 20 papers in reputed journals Scopus. She has achieved award of Program Researcher from the State Minister of Research and Technology of the Republic of Indonesia.
 

Abstract

This research was aimed to determine the effect of Pediococcus pentosaceus isolated from dadih, West Sumatra on water content, pH value, total bacteria colonies of aerobes, total lactic acid bacteria colonies, shelf life, foam power, skin irritation, and viscosity. This research uses 2,000 ml of PE goat milk (Peranakan Etawah) obtained from Sathersun Air Dingin Padang farm. Materials needed for this study include probiotics of 120 ml where 1 ml of Pediococcus pentosaceus has a dose of 2.4x109 CFU/mL, KOH of 60 g, stearic acid as much as 140 g, 180 ml aquadest, 200 ml virgin coconut oil (VCO). The research method using randomized block design (RBD) consisted of 4 treatments with 5 groups as replicates where a formula of soap consists of: 100 ml goat milk, probiotics Pediococcus pentosaceus according to treatment (A = 0 ml, B = 1 ml, C = 2 ml, D = 3 ml). The results showed that the addition of Pediococcus pentosaceus to the probiotic liquid soap was significantly different (P<0.01) lowered the water content, pH value, the total colonies of aerobic bacteria, increased the total lactic acid bacteria colonies, and shelf life, but gave no significant different effect (P>0.05) to foam power, skin irritation, and viscosity. The conclusion of the study showed that the best addition of Pediococcus pentosaceus in treatment of 3 mL with a dose of 2.4 x 109 CFU/ mL was able to lower water content by 75.56%, pH to 6.11, total colonies of aerobic bacteria - 16.40 x 103 CFU/ mL, total lactic acid bacteria colonies - 8.52 x 109 CFU/ mL, foam power 2.36, skin irritation 0.05, viscosity 0.82 , and increasing shelf life for 32 days is the best in producing goat milk liquid soap.
 

Biography

Alizée Le Riche obtained her master’s degree in cellular biology from Université Paul Sabatier in Toulouse and she is now completing her PhD from Université Paris-Diderot in collaboration with a private cosmetic industry named SILAB. Alizée was interested in dialogue between hair follicle and its macro-environment via implication of extracellular vesicles.
 

Abstract

Dermal papilla (DP) plays a critical role in hair follicle (HF) cycling, stem cell persistence but also proper skin architecture. Wnt signaling, fibroblast growth factors and the bone morphogenetic protein (BMP) pathway are crucial for early DP development and maturation. PDGF-AA is another epidermal factor which contributes to the formation of DP. Intact DP or DP cells (DPCs) at ealy passages can be engrafted with epidermal cells to reconstitute HF on mice. However DPCs gradually lost their regenerative capacity after being passaged. Sphere formation increases the hair-inductive activity of cultured human DPCs that display expression profiles different from DPCs cultured in 2D but with many similarities to intact DPCs. To restore in vitro, their regenerative capacity, primary DPCs cultivated in 2D for 5 passages were treated with exosomes (EVs) purified from dermal fibroblasts (DFs) stimulated by both bFGF and PDGF-AA. 48h after treatment, expression profiles were compared to untreated cells and DPCs cultivated as spheres. Cell proliferation of EVstreated DPCs was enhanced while a-SMA production was drastically reduced. EVs treatment restored the spheroid DPCs expression profile by recapitulating both the activation of Wnt pathway through Norrin (NDP) and the repression of two BMP antagonists Grem-1 and Bambi. Remarkably, these EVs, and not the soluble growth factors, enhanced the survival and growth of HF cultivated exvivo. EVs could become a valuable tool to maintain and restore DPC activity and HF cycling. These EVs could counteract human male androgenetic alopecia.